Batelapine → Batelapine Maleate

HRID 1982128Notes

Reaction equation

HRID 1982128 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]=[C:6]([N:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)[N:5]2[N:22]=1.[C:23]([OH:30])(=[O:29])/[CH:24]=[CH:25]\[C:26]([OH:28])=[O:27]>C(O)(C)C>[C:23]([OH:30])(=[O:29])/[CH:24]=[CH:25]\[C:26]([OH:28])=[O:27].[CH3:1][C:2]1[N:3]=[C:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]=[C:6]([N:15]3[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH2:20]3)[N:5]2[N:22]=1

Participants

4

Reactant 2

HCID 60717BatelapineHCID 444266Maleic Acid

Product 1

HCID 6435804Batelapine Maleate

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

A solution of 2-methyl-5-(4-methyl-1-piperazinyl)-11H-1,2,4-triazolo-[2,3-c][1,3]benzodiazepine in isopropanol is treated with a solution of an equimolar quantity of maleic acid in isopropanol to give 2-methyl-5-(4-methyl-1-piperazinyl)-11H-1,2,4-triazolo[2,3-c][1,3]-benzodiazepine monomaleate, m.p. 206°-208°, representing a salt of the compound of formula I wherein R1 and R2 =CH3, R3 -R6 =H and CnH2n =CH2CH2.

Sources & evidence

ORD record
ord-31eeb760f417487e95d946e4ad86550a
Source dataset
uspto-grants-1986_06
Patent number
US04595535

Reaction notes

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