1,1'-Carbonyldiimidazole → HCID 54437824, compound

HRID 1982135Notes

Reaction equation

HRID 1982135 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH2:4][C:5]1[N:9]=[C:8]([S:10][CH3:11])[NH:7][N:6]=1.[C:16](N1C=CN=C1)(N1C=CN=C1)=[O:17]>C(Cl)Cl>[CH3:11][S:10][C:8]1[N:9]=[C:5]2[CH2:4][C:3]3[CH:12]=[CH:13][CH:14]=[CH:15][C:2]=3[NH:1][C:16](=[O:17])[N:6]2[N:7]=1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 178503406HCID 178503406, compound

Product 1

HCID 54437824HCID 54437824, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 7 g of 3-(o-aminobenzyl)-5-methylmercapto-1,2,4-triazole, 5.26 g of 1,1'-carbonyldiimidazole and 179 ml of methylene chloride is heated at reflux overnight. Most of the solvent is removed in vacuo, the solids are filtered and washed with small amount of methylene chloride to give 2-methylmercapto-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine-5(6H)-one, m.p. 250°-252° (intermediate 5/b).

Workup

  1. temperatureis heated
  2. temperatureat reflux overnight
  3. customMost of the solvent is removed in vacuo
  4. filtrationthe solids are filtered
  5. washwashed with small amount of methylene chloride

Sources & evidence

ORD record
ord-995b2c25d5db4e6fbabf38ef6b7321d1
Source dataset
uspto-grants-1986_06
Patent number
US04595535

Reaction notes

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