反应详情

A solution of benzylsulfamoyl chloride (168 g) in anhydrous THF (300 ml) is added dropwise to a stirred solution of N-carbomethoxy-O-methylisourea (107 g) and triethylamine (90 g) in anhydrous THF (800 ml) under nitrogen at -70° C. The resulting suspension is warmed to RT, filtered and the filtrate evaporated in vacuo. The residue is partitioned between methylene chloride and 0.5N aq. HCl. The organic layer is dried, filtered, and concentrated in vacuo affording the desired product as an oil.

1. filtrationfiltered
2. customthe filtrate evaporated in vacuo
3. customThe residue is partitioned between methylene chloride and 0.5N aq. HCl
4. customThe organic layer is dried
5. filtrationfiltered
6. concentrationconcentrated in vacuo