反应详情

A solution of the benzamidine compound from Step 2. above (0.5 g) in THF (20 ml) is added to a suspension of NaH (110 mg of 60% mineral oil suspension, washed) in THF (10 ml), and the reaction mixture refluxed for about four hours. The mixture is poured into H2O, extracted with diethyl ether, the etheral layer washed, dried and evaporated affording the desired product.

1. temperaturethe reaction mixture refluxed for about four hours
2. extractionextracted with diethyl ether
3. washthe etheral layer washed
4. customdried
5. customevaporated