HCID 13645890, compound → HCID 14203029, compound

HRID 1982263Notes

Reaction equation

HRID 1982263 reaction equation
[O:1]1[CH2:21][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([Cl:12])[C:6]=1[O:13]CC1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[O:1]1[CH2:21][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([Cl:12])[C:6]=1[OH:13]

Participants

4

Reactant 1

HCID 13645890HCID 13645890, compound

Product 1

HCID 14203029HCID 14203029, compoundYield 106.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In 140 ml of ethyl acetate, 5.595 g of 1-(2,3-epoxypropyloxy)-2-benzyloxy-3,4-dichlorobenzene is hydrogenated under atmospheric pressure using 1.65 g of 5% palladium on carbon (50% moisture) as catalyst (for 20 minutes, 625 ml of hydrogen gas is absorbed.). After the catalyst is filtered off, the filtrate is evaporated to give 4.3 g of 1-(2,3-epoxypropyloxy)-2-hydroxy-3,4-dichlorobenzene.

Workup

  1. custom(for 20 minutes, 625 ml of hydrogen gas is absorbed.)
  2. filtrationAfter the catalyst is filtered off
  3. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-d4bc558cffe04c2cbdfda504c172827b
Source dataset
uspto-grants-1986_06
Patent number
US04595767

Reaction notes

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