HRID1982305

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(C)C

HCID178501441

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1)C(C)C

HCID178501449

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

470 mg of Boc-Pro-His-Pro-Phe-His-Sta-Val-Tyr-Lys(Boc)-OMe are dissolved at 25° in 2.3 ml of 95% strength TFA and the whole is left to stand for 30 minutes. The H-Pro-His-Pro-Phe-His-Sta-Val-Tyr-Lys-OMe formed is precipitated at 0° in pulverulent form as the trifluoroacetate by the addition of 20 ml of diisopropyl ether, is filtered off and dried; Rf (C)=0.36; Rf (D)=0.24.

WORKUP

后处理

waitthe whole is left

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ceb707e9cf824f5faa50c55a8285b760
来源数据集: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04595677
来源说明: uspto-grants-1986_06

反应 SMILES

[N:1]1(C(OC(C)(C)C)=O)[CH2:93][CH2:92][CH2:91][C@H:2]1[C:3]([NH:5][C@H:6]([C:13]([N:15]1[CH2:90][CH2:89][CH2:88][C@H:16]1[C:17]([NH:19][C@H:20]([C:28]([NH:30][C@H:31]([C:38]([NH:40][C@H:41]([C@H:46]([CH2:48][C:49]([NH:51][C@H:52]([C:56]([NH:58][C@H:59]([C:68]([NH:70][C@H:71]([C:84]([O:86][CH3:87])=[O:85])[CH2:72][CH2:73][CH2:74][CH2:75][NH:76]C(OC(C)(C)C)=O)=[O:69])[CH2:60][C:61]1[CH:66]=[CH:65][C:64]([OH:67])=[CH:63][CH:62]=1)=[O:57])[CH:53]([CH3:55])[CH3:54])=[O:50])[OH:47])[CH2:42][CH:43]([CH3:45])[CH3:44])=[O:39])[CH2:32][C:33]1[N:37]=[CH:36][NH:35][CH:34]=1)=[O:29])[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:18])=[O:14])[CH2:7][C:8]1[N:12]=[CH:11][NH:10][CH:9]=1)=[O:4]>C(O)(C(F)(F)F)=O>[NH:1]1[CH2:93][CH2:92][CH2:91][C@H:2]1[C:3]([NH:5][C@H:6]([C:13]([N:15]1[CH2:90][CH2:89][CH2:88][C@H:16]1[C:17]([NH:19][C@H:20]([C:28]([NH:30][C@H:31]([C:38]([NH:40][C@H:41]([C@H:46]([CH2:48][C:49]([NH:51][C@H:52]([C:56]([NH:58][C@H:59]([C:68]([NH:70][C@H:71]([C:84]([O:86][CH3:87])=[O:85])[CH2:72][CH2:73][CH2:74][CH2:75][NH2:76])=[O:69])[CH2:60][C:61]1[CH:62]=[CH:63][C:64]([OH:67])=[CH:65][CH:66]=1)=[O:57])[CH:53]([CH3:55])[CH3:54])=[O:50])[OH:47])[CH2:42][CH:43]([CH3:44])[CH3:45])=[O:39])[CH2:32][C:33]1[N:37]=[CH:36][NH:35][CH:34]=1)=[O:29])[CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:18])=[O:14])[CH2:7][C:8]1[N:12]=[CH:11][NH:10][CH:9]=1)=[O:4]