Potassium Bromide → 6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carbonitrile

HRID 1982374Notes

Reaction equation

[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]#[N:18])=[CH:16][C:3]1=2.[K+].[Br-]>>[OH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]#[N:18])=[CH:16][C:3]1=2

Participants

Reactant 2

HCID 253877Potassium Bromide

HCID 124468252-Cyano-6,11-dihydro-11-oxodibenz[b,e]oxepin

Product 1

HCID 541175056,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carbonitrile

Procedure

In a similar manner as above, 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carbonitrile XII was prepared from the oxepin-carbonitrile XI in a quantitative yield. IR spectrum (KBr tablet, cm-1): 2230, 1610, 1500, 1260, 1240, 1000; NMR spectrum (CDCl3 +d6DMSO, δ-value, ppm): 5.23(d, 1H), 5.72(d, 1H), 5.88(d, 1H), 6.15(d, 1H), 6.7-7.9(m, 7H).

Sources & evidence

ORD record: ord-11276c911d5444238e83b31765168872
Source dataset: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04596804

Reaction notes

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