Potassium Carbonate → HCID 136087603, compound

HRID 1982471Notes

Reaction equation

HRID 1982471 reaction equation
[C:1]([C:3]1[N:4]=[CH:5][C:6]2[NH:7][C:8]3[C:13]([C:14]=2[CH:15]=1)=[CH:12][CH:11]=[CH:10][CH:9]=3)#[N:2].Cl.[NH2:17][OH:18].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH:5]1[C:6]2[NH:7][C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]=2[CH:15]=[C:3]([C:1](=[N:17][OH:18])[NH2:2])[N:4]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 200599829H-beta-Carboline-3-carbonitrile

Product 1

HCID 136087603HCID 136087603, compoundYield 85.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.4 g of 3-cyano-beta-carboline, 1.1 g of hydroxylamine-hydrochloride, 200 ml of 99% ethanol and 5.2 ml of a potassium carbonate solution (2.2 g of potassium carbonate in 10 ml of water) is boiled in an oil bath at 90° C. outside temperature for 22 h at the reflux. The reaction mixture is filtered hot. The filtrate is concentrated. The residue is treated with 100 ml of water. The precipitate is filtered off, washed with water and dried in air. 2.4 g of beta-carboline-3-carboxylic-acid-amide-oxime with a m.p. of 159°-163° C. is obtained.

Workup

  1. filtrationThe reaction mixture is filtered hot
  2. concentrationThe filtrate is concentrated
  3. additionThe residue is treated with 100 ml of water
  4. filtrationThe precipitate is filtered off
  5. washwashed with water
  6. customdried in air

Sources & evidence

ORD record
ord-807f1e549f6c4b6694f4e4b774539a24
Source dataset
uspto-grants-1986_06
Patent number
US04596808

Reaction notes

Loading…