Hydrogen Peroxide → HCID 13604325, compound

HRID 1982487Notes

Reaction equation

HRID 1982487 reaction equation
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([S:8][CH3:9])[S:5][C:4]=1[C:10]1[NH:11][C:12]2[C:13]([N:18]=1)=[N:14][CH:15]=[CH:16][CH:17]=2.[OH:19]O>>[CH3:1][O:2][C:3]1[CH:7]=[C:6]([S:8]([CH3:9])=[O:19])[S:5][C:4]=1[C:10]1[NH:11][C:12]2[C:13]([N:18]=1)=[N:14][CH:15]=[CH:16][CH:17]=2

Participants

3

Reactant 2

HCID 784Hydrogen PeroxideHCID 13604324HCID 13604324, compound

Product 1

HCID 13604325HCID 13604325, compound

Procedure

3.80 g (13.7 mmoles) of the 2-(3-methoxy-5-methylthio-2-thienyl)-1H-imidazo[4,5-b]pyridine, obtained in Example 1, are dissolved in 80 ml of glacial acid, 1.63 g (14.4 mmoles) of 30% aqueous solution of hydrogen peroxide are added and stirred at room temperature for 30 hours. The solution is concentrated in vacuo, the residue is dissolved in a small amount of water, neutralized with a saturated solution of sodium hydrogen carbonate, and the precipitating crystals are aspirated and dried. Yield: 3.95 g (98%), m.p. (ethanol) 233°-235° C. (dec.).

Workup

  1. additionare added
  2. concentrationThe solution is concentrated in vacuo
  3. dissolutionthe residue is dissolved in a small amount of water
  4. customdried

Sources & evidence

ORD record
ord-2af157cdeace4b38b8aa95aa1803b94a
Source dataset
uspto-grants-1986_06
Patent number
US04596830

Reaction notes

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