反应详情

温度

80 °C

20 g (88.6 mmol) of 4-chloro-3-nitrophenyl cyclopropyl ketone is added to a solution of 65 m of 32% HBr/acetic acid in 300 ml acetic acid and heated to 80° C. for 5 hr. The reaction mixture is cooled to room temperature and poured nto 1 L of 10% potassium carbonate solution, dried over MgSO4 filtered and treated with charcoal. The solvent is removed in vacuo, and the residue is crystallized from ether to provide the title compound.

1. temperatureThe reaction mixture is cooled to room temperature
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. additiontreated with charcoal
5. customThe solvent is removed in vacuo
6. customthe residue is crystallized from ether