Potassium Carbonate → HCID 13633265, compound

HRID 1982527Notes

Reaction equation

HRID 1982527 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[BrH:16].C(O)(=O)C.C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C>[Br:16][CH2:3][CH2:2][CH2:1][C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1)=[O:5]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 12682594-Chloro-3-nitrophenyl cyclopropyl ketoneHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 13633265HCID 13633265, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

20 g (88.6 mmol) of 4-chloro-3-nitrophenyl cyclopropyl ketone is added to a solution of 65 m of 32% HBr/acetic acid in 300 ml acetic acid and heated to 80° C. for 5 hr. The reaction mixture is cooled to room temperature and poured nto 1 L of 10% potassium carbonate solution, dried over MgSO4 filtered and treated with charcoal. The solvent is removed in vacuo, and the residue is crystallized from ether to provide the title compound.

Workup

  1. temperatureThe reaction mixture is cooled to room temperature
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. additiontreated with charcoal
  5. customThe solvent is removed in vacuo
  6. customthe residue is crystallized from ether

Sources & evidence

ORD record
ord-a4f60d8f66334188b2393a08d693cf29
Source dataset
uspto-grants-1986_06
Patent number
US04596872

Reaction notes

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