Acetone → 6,8-Dichloro-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

HRID 198278Notes

Reaction equation

HRID 198278 reaction equation
[CH3:28][I:29].[CH3:31][C:32](=[O:33])[CH3:34].[CH:35]([N:36]([CH:37]([CH3:38])[CH3:39])[CH2:40][CH3:41])([CH3:42])[CH3:43].[Cl:1][c:2]1[cH:3][c:4]2[c:9]([c:10]([Cl:12])[cH:11]1)[CH2:8][N+:7]([CH3:13])([CH3:14])[CH2:6][CH:5]2[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[ClH:30].[O-:21][C:22]([C:23]([F:24])([F:25])[F:26])=[O:27]>>[Cl:1][c:2]1[cH:3][c:4]2[c:9]([c:10]([Cl:12])[cH:11]1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1

Participants

7

Reactant 6

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 81531DiisopropylethylamineHCID 84468TrifluoroacetateHCID 121125146,8-Dichloro-2,2-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolinium

Product 1

HCID 223868076,8-Dichloro-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

Sources & evidence

ORD record
ord-5955886bad4b40329fd00b1677dcd28b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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