Hydrochloric Acid → HCID 22350156, compound

HRID 1982791Notes

Reaction equation

HRID 1982791 reaction equation
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH2:20][CH2:21][NH2:22])[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:23]>C(OCC)(=O)C.C(OCC)C>[ClH:23].[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH2:20][CH2:21][NH2:22])[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 102678372-[1-(Benzenesulfonyl)indol-4-yl]oxyethanamine

Product 1

HCID 22350156HCID 22350156, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-{[1-(phenylsulfonyl)-1H-indole-4-yl]oxy}ethylamine (0.20 g, 0.63 mmol) in ethyl acetate is treated with HCl in diethyl ether (1M, 0.7 ml) and filtered. The filtercake is dried in vacuo to afford the title product as a pink solid, 0.21 g, mp 198-200° C., identified by NMR and mass spectral analyses.

Workup

  1. filtrationfiltered
  2. customThe filtercake is dried in vacuo

Sources & evidence

ORD record
ord-e3394b91c1b846ca9615be101efcc27c
Source dataset
uspto-grants-2009_06
Patent number
US07541358B2

Reaction notes

Loading…