Benzyl Bromide → HCID 11625775, compound

HRID 1982896Notes

Reaction equation

HRID 1982896 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6]OC2C3NC(C)=C(C)C=3C=NC=2)=[CH:4][CH:3]=1.Cl.[Cl:22][C:23]1[CH:41]=[CH:40][C:26]([CH2:27][O:28][C:29]2[C:30]3[NH:37][C:36]([CH3:38])=[C:35]([CH3:39])[C:31]=3[CH:32]=[N:33][CH:34]=2)=[CH:25][CH:24]=1.C(=O)(O)[O-].[Na+].C(Br)C1C=CC=CC=1>>[ClH:1].[CH2:6]([N:37]1[C:30]2[C:29]([O:28][CH2:27][C:26]3[CH:40]=[CH:41][C:23]([Cl:22])=[CH:24][CH:25]=3)=[CH:34][N:33]=[CH:32][C:31]=2[C:35]([CH3:39])=[C:36]1[CH3:38])[C:5]1[CH:19]=[CH:20][CH:2]=[CH:3][CH:4]=1

Participants

5

Reactant 4

HCID 7498Benzyl BromideHCID 516892Sodium BicarbonateHCID 11594951HCID 11594951, compoundHCID 11594952HCID 11594952, compound

Product 1

HCID 11625775HCID 11625775, compoundYield 38.8%

Procedure

In accordance with the same procedures as in Example 2, except for using 7-(4-chlorobenzyloxy)-2,3-dimethyl-1H-pyrrolo[3,2-c]pyridine obtained by treating the compound of Example 18 with a saturated sodium bicarbonate solution and benzyl bromide, the titled compound was obtained as a white solid. (Yield: 38.8% )

Workup

  1. customobtained

Sources & evidence

ORD record
ord-2149445087784920b14ff6e40b634db0
Source dataset
uspto-grants-2009_06
Patent number
US07541366B2

Reaction notes

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