Acetone → HCID 23149150, compound

HRID 1983029Notes

Reaction equation

HRID 1983029 reaction equation
C(C1N=C[NH:6][N:5]=1)(C)C.[CH2:9]=O.C([N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])C.C[C:19](C)=[O:20]>>[CH:16]([N:13]1[CH:14]=[CH:15][N:6]([CH2:19][OH:20])[NH:5]1)([CH3:17])[CH3:9]

Participants

5

Reactant 4

HCID 180AcetoneHCID 712FormaldehydeHCID 8471TriethylamineHCID 178440198HCID 178440198, compound

Product 1

HCID 23149150HCID 23149150, compound

Conditions

Temperature
150 °C

Procedure

The mixture of 1.15 g of 3-i-propyl-1H-1,2,4-triazole, 0.94 g of paraformaldehyde and 0.14 g of triethylamine was stirred at 150° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered. The filtrate was concentrated under reduced pressure. Hexane was added to the obtained residue, as a result, a crystal was formed. The crystal was collected to obtain 1.28 g of 3-i-propyl-1H-triazole-1-ylmethanol.

Workup

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. additionHexane was added to the obtained residue, as a result
  5. customa crystal was formed
  6. customThe crystal was collected

Sources & evidence

ORD record
ord-a084388f6a994788b3f6a58180b37da6
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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