Trifluoroacetic acid → HCID 68845319, compound

HRID 1983566Notes

Reaction equation

HRID 1983566 reaction equation
[CH2:1]([C:6]1[N:11]=[CH:10][C:9]([NH:12][C:13]([C@@H:15]2[CH2:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:17][N:16]2C(OC(C)(C)C)=O)=[O:14])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([C:6]1[N:11]=[CH:10][C:9]([NH:12][C:13]([C@@H:15]2[CH2:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:17][NH:16]2)=[O:14])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131727458HCID 131727458, compound

Product 1

HCID 68845319HCID 68845319, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The crude product from step 1 was dissolved in methylene chloride (6.4 mL) and treated with trifluoroacetic acid (3.6 mL). After stirring for 1.5 hours the reaction was concentrated and the residue was partitioned between methylene chloride and aqueous sodium bicarbonate solution. The organic layer was dried (sodium sulfate) and concentrated to afford a gray-green solid.

Workup

  1. concentrationwas concentrated
  2. customthe residue was partitioned between methylene chloride and aqueous sodium bicarbonate solution
  3. dry with materialThe organic layer was dried (sodium sulfate)
  4. concentrationconcentrated
  5. customto afford a gray-green solid

Sources & evidence

ORD record
ord-80d24c805bff4921a38add119608acce
Source dataset
uspto-grants-2009_06
Patent number
US07541466B2

Reaction notes

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