Hydrochloric Acid → HCID 178456383, compound

HRID 1984028Notes

Reaction equation

C(OC([NH:8][NH:9][C:10](=[O:35])[C:11]1[CH:16]=[CH:15][C:14]([O:17][C@H:18]2[CH2:23][CH2:22][C@H:21]([C:24]([N:26]3[CH2:31][CH2:30][N:29]([CH:32]([CH3:34])[CH3:33])[CH2:28][CH2:27]3)=[O:25])[CH2:20][CH2:19]2)=[CH:13][CH:12]=1)=O)(C)(C)C.Cl>O1CCOCC1.CO>[CH:32]([N:29]1[CH2:30][CH2:31][N:26]([C:24]([C@H:21]2[CH2:22][CH2:23][C@H:18]([O:17][C:14]3[CH:13]=[CH:12][C:11]([C:10]([NH:9][NH2:8])=[O:35])=[CH:16][CH:15]=3)[CH2:19][CH2:20]2)=[O:25])[CH2:27][CH2:28]1)([CH3:34])[CH3:33]

Participants

Conditions

Temperature: 40 °C

Procedure

A mixture of 440 mg (0.90 mmol) of trans-N′-{4-[4-(4-Isopropyl-piperazine-1-carbonyl)-cyclohexyloxy]-benzoyl}-hydrazinecarboxylic acid tert-butyl ester, 1.53 ml (6.12 mmol) of 4M hydrochloric acid in 1,4-dioxane solution and 4 ml of methanol was stirred for 4 h at 40° C. The mixture was evaporated to dryness to yield 0.44 g of the title compound. MS (m/e): 389.2 (MH+).

Workup

customThe mixture was evaporated to dryness

Sources & evidence

ORD record: ord-8e5133f91dc140a7837cf2431bbc3458
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544683B2

Reaction notes

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