Triethylamine → HCID 178456382, compound

HRID 1984034Notes

Reaction equation

HRID 1984034 reaction equation
[C:1]([C:3]1[CH:26]=[CH:25][C:6]([O:7][C@H:8]2[CH2:13][CH2:12][C@H:11]([C:14]([N:16]3[CH2:21][CH2:20][N:19]([CH:22]([CH3:24])[CH3:23])[CH2:18][CH2:17]3)=[O:15])[CH2:10][CH2:9]2)=[CH:5][CH:4]=1)#[N:2].Cl.[NH2:28][OH:29].C(N(CC)CC)C>C(O)C>[OH:29][NH:28][C:1](=[NH:2])[C:3]1[CH:4]=[CH:5][C:6]([O:7][C@H:8]2[CH2:13][CH2:12][C@H:11]([C:14]([N:16]3[CH2:17][CH2:18][N:19]([CH:22]([CH3:23])[CH3:24])[CH2:20][CH2:21]3)=[O:15])[CH2:10][CH2:9]2)=[CH:25][CH:26]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 178456380HCID 178456380, compound

Product 1

HCID 178456382HCID 178456382, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.15 g (0.42 mmol) of trans-[4-(4-cyano-phenoxy)-cyclohexyl]-(4-isopropyl-piperazin-1-yl)-methanone, 0.118 g (1.69 mmol) of hydroxylamine hydrochloride, 0.24 ml (1.73 mmol) of triethylamine in 3 ml ethanol was refluxed for 1 hr. The mixture was evaporated to dryness to yield 0.34 g (84% yields, about 40% purity) of the titled compound. MS (m/e): 389.3 (MH+).

Workup

  1. temperaturewas refluxed for 1 hr
  2. customThe mixture was evaporated to dryness
  3. customto yield

Sources & evidence

ORD record
ord-215669947daa49cd96b8355184f777a5
Source dataset
uspto-grants-2009_06
Patent number
US07544683B2

Reaction notes

Loading…