反应详情

A solution of 4-[2-Amino-4-chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-but-3-yn-1-ol (see example 2) (1.53 g) and NaH (95%, 0.38 g) in anhydrous DMA (25 mL) was treated with ethyl chloroformate (1.5 mL) at 0-23° C. for 0.5 h. Work-up and preparative HPLC gave the title compound. HPLC Rt=5.65 min.