Acetic Anhydride → HCID 178475360, compound

HRID 1984223Notes

Reaction equation

HRID 1984223 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[C:4]([C:13]([NH2:15])=[O:14])[N:3]=1.C(N(CC)CC)C.[C:23](OC(=O)C)(=[O:25])[CH3:24]>CN(C=O)C.C(O)C>[C:13]([C:4]1[N:3]=[C:2]([OH:1])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][C:23](=[O:25])[CH3:24])[CH:10]=2)[N:5]=1)(=[O:14])[NH2:15]

Participants

6

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 178513828HCID 178513828, compound

Product 1

HCID 178475360HCID 178475360, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6228DimethylformamideSolvent2×

Procedure

4,6-Dihydroxy-quinazoline-2-carboxylic acid amide (12 mmol) are dissolved in warm DMF (20 ml) and triethylamine (13.2 mmol) is added to the stirred mixture. After cooling to RT a solution of acetic acid anhydride in DMF (10 ml) is added dropwise and the mixture is stirred overnight. The solvent is removed and the solid material formed is suspended in ethanol and the solid filtered of and dried (vacuum). A powder with mp. 250° C. is obtained.

Workup

  1. additionis added dropwise
  2. customThe solvent is removed
  3. customthe solid material formed
  4. filtrationthe solid filtered of and
  5. customdried (vacuum)
  6. customA powder with mp. 250° C. is obtained

Sources & evidence

ORD record
ord-d0c25c5e386a45249f83bb27e63af4c2
Source dataset
uspto-grants-2009_06
Patent number
US07544688B2

Reaction notes

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