反应详情

4,6-Dihydroxy-quinazoline-2-carboxylic acid amide (12 mmol) are dissolved in warm DMF (20 ml) and triethylamine (13.2 mmol) is added to the stirred mixture. After cooling to RT a solution of acetic acid anhydride in DMF (10 ml) is added dropwise and the mixture is stirred overnight. The solvent is removed and the solid material formed is suspended in ethanol and the solid filtered of and dried (vacuum). A powder with mp. 250° C. is obtained.

1. additionis added dropwise
2. customThe solvent is removed
3. customthe solid material formed
4. filtrationthe solid filtered of and
5. customdried (vacuum)
6. customA powder with mp. 250° C. is obtained