反应详情

To a mixture of 7-(4-formylphenyl)-6-phenylpyrido[2,3-d]pyrimidine-2-carbonitrile (2-5) (0.100 g, 0.297 mmol) in 2:1 THF:H2O (6 mL) was added K2CO3 (16 mg) and urea peroxide (0.112 g, 1.19 mmol). The mixture was stirred for 1 hr @ rt when it was concentrated, diluted with 1:1 H2—O:saturated aqueous Na2CO3, and extracted 3× with CH2Cl2. The combined organics were dried (anhd. Na2SO4), filtered, and concentrated. The crude material was used directly in the next step. LRMS, calc'd: 355.0, found: 355.0

1. concentrationwas concentrated
2. additiondiluted with 1:1 H2—O
3. extractionsaturated aqueous Na2CO3, and extracted 3× with CH2Cl2
4. dry with materialThe combined organics were dried (anhd. Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated