反应详情

温度

150 °C

N-Methylpiperazine (2.0 mL) was added to N-(3,5-dimethylphenyl)-2-(2-fluoropyridin-4-ylmethylthio)pyridine-3-carboxamide (Reference compound No. 3-1, 100 mg, 0.27 mmol) at room temperature, then the vessel was sealed and the reaction mixture was stirred for 3 hours at 150° C. The mixture was cooled to room temperature, ethyl acetate (20 mL) was added to the reaction mixture, and then the whole was washed with brine (20 mL) and dried over anhydrous magnesium sulfate. The organic layer was evaporated under reduced pressure, and the resulting solid was filtered off with ethyl acetate to give 39 mg of the target compound as a colorless crystal. (Yield 32%)

1. custom3-1, 100 mg, 0.27 mmol) at room temperature, then the vessel was sealed
2. temperatureThe mixture was cooled to room temperature
3. washthe whole was washed with brine (20 mL)
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe organic layer was evaporated under reduced pressure
6. filtrationthe resulting solid was filtered off with ethyl acetate