Isobutyryl chloride → HCID 57717953, compound

HRID 1984822Notes

Reaction equation

HRID 1984822 reaction equation
[CH3:1][O:2][C:3](=[O:40])[C@H:4]([NH:20][C:21]([C:23]1[CH:24]=[C:25]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=2)[CH:26]=[CH:27][C:28]=1[NH2:29])=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([Cl:19])[CH:13]=2)=[CH:8][CH:7]=1.[C:41](Cl)(=[O:45])[CH:42]([CH3:44])[CH3:43]>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:40])[C@H:4]([NH:20][C:21]([C:23]1[CH:24]=[C:25]([C:30]2[CH:31]=[CH:32][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:34][CH:35]=2)[CH:26]=[CH:27][C:28]=1[NH:29][C:41](=[O:45])[CH:42]([CH3:44])[CH3:43])=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([Cl:19])[CH:13]=2)=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 62325Isobutyryl chlorideHCID 68868279HCID 68868279, compound

Product 1

HCID 57717953HCID 57717953, compoundYield 84.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 20 mg (0.035 mmol) of 2(R)-[(4-amino-4′-trifluoromethyl-biphenyl-3-carbonyl)-amino]-3-(3′-chloro-4′-fluoro-biphenyl-4-yl)-propionic acid methyl ester in 1 mL of DCM was added 12 mg (0.11 mmol) of isobutyryl chloride following general procedure M to give the title compound (19 mg).

Sources & evidence

ORD record
ord-cbbd74a770d642cd8aed2506c1abb2ee
Source dataset
uspto-grants-2009_06
Patent number
US07544699B2

Reaction notes

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