HCID 68850270, compound → HCID 86610864, compound

HRID 1984894Notes

Reaction equation

HRID 1984894 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:24]=[C:23]([N:25]([CH3:27])[CH3:26])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[CH3:26][N:25]([CH3:27])[C:23]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:24]=1

Participants

4

Reactant 1

HCID 68850270HCID 68850270, compound

Product 1

HCID 86610864HCID 86610864, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

To a solution of N2-(1-benzyl-piperidin-4-yl)-N4,N4-dimethyl-quinazoline-2,4-diamine (1.80 g, 4.98 mmol) in MeOH (18 mL) was added 20% Pd(OH)2 (360 mg). The mixture was stiffed at 50° C. under hydrogen atmosphere for 3 days, filtered through a pad of celite, and concentrated to give N4,N4-dimethyl-N2-piperidin-4-yl-quinazoline-2,4-diamine (1.33 g, 99%) as a pale yellow solid.

Workup

  1. filtrationfiltered through a pad of celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-7c5b5dddacfd478ca10813870b39d218
Source dataset
uspto-grants-2009_06
Patent number
US07544690B2

Reaction notes

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