反应详情

3-Trifluoromethylbenzyl bromide (0.03 mL, 0.175 mmol, d=1.565) and tetrabutyl ammonium iodide (catalytic amount) are added to a 0° C. suspension of 2-(2-Fluoro-phenoxy)-2-methyl-3-{4-[2-(3-methyl-2-oxo-imidazolidin-4-yl)-ethoxy]-phenyl}-propionic acid ethyl ester (0.052 g, 0.117 mmol) and sodium hydride (0.012 g, 0.292 mmol, 60% suspension on mineral oil), and pre-stirred for 1 h at ambient temperature. The reaction mixture is stirred at ambient temperature for 18 h, diluted with ethyl acetate, and washed with 1N HCl, water, and brine. The organic layer is dried, concentrated, and carried into the next step. MS [EI+] 603 (M+H)+.

1. stirringThe reaction mixture is stirred at ambient temperature for 18 h
2. washwashed with 1N HCl, water, and brine
3. customThe organic layer is dried
4. concentrationconcentrated