Hydrochloric Acid → HCID 68867561, compound

HRID 1985175Notes

Reaction equation

HRID 1985175 reaction equation
C[O:2][C:3](=[O:35])[C:4]([CH3:34])([CH3:33])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH:15]2[CH2:19][N:18]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=3)[C:17](=[O:31])[N:16]2[CH3:32])=[CH:8][CH:7]=1.[OH-].[Na+].Cl>CO>[CH3:33][C:4]([CH3:34])([CH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:12][CH2:13][CH2:14][CH:15]2[CH2:19][N:18]([CH2:20][C:21]3[CH:22]=[CH:23][C:24]([C:27]([F:28])([F:30])[F:29])=[CH:25][CH:26]=3)[C:17](=[O:31])[N:16]2[CH3:32])=[CH:10][CH:11]=1)[C:3]([OH:35])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 688672152,2-Dimethyl-3-(4-{2-[3-methyl-2-oxo-1-(4-trifluoromethyl-benzyl)-imidazolidin-4-yl]-ethoxy}-phenyl)-propionic acid methyl ester

Product 1

HCID 68867561HCID 68867561, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the ester obtained from Step A (66 mg, 0.13 mmol) in methanol (1.5 ml) is added 5N NaOH (0.3 ml, 1.5 mmol), and the mixture stirred for 20 hours at ambient temperature. The mixture is poured into 1N HCl (20 ml), then extracted with ethyl acetate (2×15 ml). The combined ethyl acetate extracts were washed with water, brine, dried (Na2SO4), and concentrated to a foam (62 mg, 97%.

Workup

  1. extractionextracted with ethyl acetate (2×15 ml)
  2. washThe combined ethyl acetate extracts were washed with water, brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated to a foam (62 mg, 97%

Sources & evidence

ORD record
ord-b7519f8be31048a184821166f624407b
Source dataset
uspto-grants-2009_06
Patent number
US07544812B2

Reaction notes

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