反应详情

7.2 g of (4S)-3-[(3R,2S)-3-(4-Ethoxyphenyl)-3-hydroxy-2-isopropoxypropanoyl]-4-benzyl-1,3-oxazolan-2-one was dissolved in 200 ml of trifluoroacetic acid, 40 ml of triethylsilane was added, and the mixture was stirred for 24 hours. The solvent was evaporated, and the residue was purified by silica gel column chromatography (elution solvent: hexane-ethyl acetate), to give 7.0 g of (4S)-3-[(2S)-3-(4-ethoxyphenyl)-2-isopropoxypropanoyl]-4-benzyl-1,3-oxazolan-2-one as a colorless solid.

1. customThe solvent was evaporated
2. customthe residue was purified by silica gel column chromatography (elution solvent: hexane-ethyl acetate)