tert-Butyl acrylate → HCID 57720149, compound

HRID 1985627Notes

Reaction equation

HRID 1985627 reaction equation
[C:1]([O:5][C:6](=[O:12])[CH2:7][NH:8][CH2:9][CH2:10][NH2:11])([CH3:4])([CH3:3])[CH3:2].[C:13]([O:17][C:18](=[O:21])[CH:19]=[CH2:20])([CH3:16])([CH3:15])[CH3:14]>CC(O)C>[C:13]([O:17][C:18](=[O:21])[CH2:19][CH2:20][NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:12])([CH3:16])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 15458tert-Butyl acrylateHCID 15098046HCID 15098046, compound

Product 1

HCID 57720149HCID 57720149, compoundYield 0.1%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
60 °C

Procedure

To the solution of (2-amino-ethylamino)-acetic acid tert-butyl ester (1.0 mL, 6.32 mmol) in i-PrOH (50 mL) was added acrylic acid tert-butyl ester (309.1 μL, 2.11 mmol). The suspension was heated for 48 hours at 60° C. The solvent was evaporated and product was purificated by column chromatography (DCM-MeOH—NH3=90:3:0.5) yielded the title product as colorless oil (0.45 mg).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-0ac15d45dcf74e98986e6d742313533b
Source dataset
uspto-grants-2009_06
Patent number
US07547679B2

Reaction notes

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