5-Chloro-2-nitrobenzoic acid → HCID 45444158, compound

HRID 1985689Notes

Reaction equation

HRID 1985689 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:10](Cl)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2].[CH2:14]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(OCC)(=O)C>[N+:1]([C:4]1[CH:12]=[CH:11][C:10]([N:24]2[CH2:25][CH2:26][N:21]([CH2:14][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:22][CH2:23]2)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 172865-Chloro-2-nitrobenzoic acidHCID 759941-Benzylpiperazine

Product 1

HCID 45444158HCID 45444158, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
120 °C

Procedure

The mixture of 20 g of 2-nitro-5-chlorobenzoic acid and 50 mL of N-benzylpiperazine is stirred at 120° C. for 6 hours. To the reaction mixture 250 mL of ethyl acetate is added. The precipitated yellow crystalline material is filtered off, dissolved in 200 mL of water. The pH of the mixture is adjusted to 6 with acetic acid. The precipitated material is filtered off, washed with water and dried, to obtain 30 g of the title compound. M.p.: 172° C.

Workup

  1. filtrationThe precipitated yellow crystalline material is filtered off
  2. dissolutiondissolved in 200 mL of water
  3. filtrationThe precipitated material is filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-738db53da7d842ee9801c1bd525d9c9a
Source dataset
uspto-grants-2009_06
Patent number
US07547696B2

Reaction notes

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