Sodium Thiosulfate → 4,4,4-Trifluoro-2-methylbutanal

Temperature

25 °C

To 2-methyl-4,4,4-trifluoro-1-butanol (7.5 g, 53 mmol) in methylene chloride (CH2Cl2) (125 mL) at 0° C. was added Dess-Martin periodinane (26.5 g, 63.3 mmol). The reaction mixture was warmed to 25° C. and stirred for 20 min. To this mixture was added diethyl ether (Et2O-200 mL) followed by a solution of Na2S2O3 (29.0 g, 185 mmol) in a saturated aqueous solution of sodium bicarbonate (NaHCO3) (200 mL) and 100 mL of water. The milky white mixture was stirred until both phases were homogeneous. The phases were separated and the organic extract washed with saturated aqueous NaHCO3 (25 mL) and aqueous 1 N Na2S2O3 (25 mL) and dried using magnesium sulfate (MgSO4). Solvents were removed by distillation at atmospheric pressure to give 2-methyl-4,4,4-trifluorobutanal (6.5 g, 88%). 1H nuclear magnetic resonance (NMR) spectrum matched that which was reported in the literature (J. Fluorine Chem. 36: 163-170 (1987).

1. stirringThe milky white mixture was stirred until both phases
2. customThe phases were separated
3. extractionthe organic extract
4. washwashed with saturated aqueous NaHCO3 (25 mL) and aqueous 1 N Na2S2O3 (25 mL)
5. customdried
6. customSolvents were removed by distillation at atmospheric pressure

ORD record

ord-ae80cd150ecd40e9805861835cc5fa18

Source dataset

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07547725B2