Hydrochloric Acid → HCID 67046027, compound

HRID 1986047Notes

Reaction equation

HRID 1986047 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH:7]2[CH2:12][C:11]([CH3:14])([CH3:13])[N:10](C)[C:9]([CH3:17])([CH3:16])[CH2:8]2)=[CH:4][C:3]=1[C:20]([F:23])([F:22])[F:21].CCOC(/N=N/C(OCC)=O)=O.Cl>C1(C)C=CC=CC=1>[ClH:1].[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH:7]2[CH2:12][C:11]([CH3:13])([CH3:14])[NH:10][C:9]([CH3:17])([CH3:16])[CH2:8]2)=[CH:4][C:3]=1[C:20]([F:23])([F:21])[F:22]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5462977Diethyl azodicarboxylateHCID 11695979HCID 11695979, compound

Product 1

HCID 67046027HCID 67046027, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 4-(4-chloro-3-trifluoromethyl-phenoxy)-1,2,2,6,6-pentamethyl-piperidine (1.28 g, 4.26 mmol), toluene (50 ml) and diethylazodicarboxylate (2.0 ml, 12.8 mmol) was heated at 110° C. for 8 h. Hydrochloric acid (20 ml, 2 M) was added at reflux for 2 h. The mixture was cooled on ice. The hydrochloric acid salt precipitated and was isolated by filtration. Yield 1.2 g (87%). Mp 222° C.

Workup

  1. temperatureat reflux for 2 h
  2. temperatureThe mixture was cooled on ice
  3. customThe hydrochloric acid salt precipitated
  4. customwas isolated by filtration

Sources & evidence

ORD record
ord-6da61c5fe2984d21963747daee4acc2b
Source dataset
uspto-grants-2009_06
Patent number
US07547788B2

Reaction notes

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