反应详情

温度

200 °C

A mixture of 300 mg of 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromoxanthine and 290 mg of piperazine in 5 ml of N,N-dimethylformamide is heated at 200° C. for 5 min in a microwave oven. After cooling to room temperature, the reaction mixture is treated with water and saturated sodium chloride solution and extracted with ethyl acetate. The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulphate and concentrated. The solid flask residue is triturated with diethyl ether, filtered off with suction and dried at 45° C. in a circulating air drying oven.

1. temperatureAfter cooling to room temperature
2. extractionextracted with ethyl acetate
3. washThe organic phase is washed with saturated sodium chloride solution
4. dry with materialdried over magnesium sulphate
5. concentrationconcentrated
6. customThe solid flask residue is triturated with diethyl ether
7. filtrationfiltered off with suction
8. customdried at 45° C. in a circulating air
9. customdrying oven