HCID 68867784, compound → HCID 68872025, compound

HRID 1986598Notes

Reaction equation

HRID 1986598 reaction equation
Cl[C:2]1[C:7]2[N:8]=[CH:9][C:10]3[N:11]([CH2:12][N:13]([O:15][CH3:16])[CH:14]=3)[C:6]=2[N:5]([CH2:17][CH2:18][CH3:19])[CH2:4][C:3]=1[CH3:20].[CH2:21]([Mg]Br)[CH3:22]>O1CCCC1>[CH2:21]([C:2]1[C:7]2[N:8]=[CH:9][C:10]3[N:11]([CH2:12][N:13]([O:15][CH3:16])[CH:14]=3)[C:6]=2[N:5]([CH2:17][CH2:18][CH3:19])[CH2:4][C:3]=1[CH3:20])[CH3:22]

Participants

4

Reactant 2

HCID 68867784HCID 68867784, compoundHCID 178418443HCID 178418443, compound

Product 1

HCID 68872025HCID 68872025, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

7 g of intermediate A1 are suspended in 150 ml tetrahydrofurane. 30 ml of a solution of ethyl magnesium bromide in tetrahydrofurane (3 M) are added. The mixture is stirred for 4 hours at room temperature. After filtration the solvent is removed. The crude product is purified by preparative HPLC.

Workup

  1. filtrationAfter filtration the solvent
  2. customis removed
  3. customThe crude product is purified by preparative HPLC

Sources & evidence

ORD record
ord-f9bb50700e274e97a307f5c456aa361e
Source dataset
uspto-grants-2009_06
Patent number
US07550465B2

Reaction notes

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