Hydrochloric Acid → HCID 68871501, compound

HRID 1986604Notes

Reaction equation

HRID 1986604 reaction equation
[CH3:1][C:2]1[CH2:11][N:10]([CH2:12][CH2:13][CH3:14])[C:9]2[N:8]3[CH2:15][N:16]([O:18][CH3:19])[CH:17]=[C:7]3[CH:6]=[N:5][C:4]=2[C:3]=1[CH3:20].[Cl:21]CCl.Cl>O>[ClH:21].[CH3:1][C:2]1[CH2:11][N:10]([CH2:12][CH2:13][CH3:14])[C:9]2[N:8]3[CH2:15][N:16]([O:18][CH3:19])[CH:17]=[C:7]3[CH:6]=[N:5][C:4]=2[C:3]=1[CH3:20]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 68869182HCID 68869182, compound

Product 1

HCID 68871501HCID 68871501, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 13.52 g of pure 3,4-dimethyl-8-methoxy-1-propyl-imidazo-[1,5-a]-pyrido[3,2-e]-pyrazine and 100 ml of dichloromethane 2.5 equivalents of hydrochloric acid dissolved in 100 ml of water were added. The mixture was vigorously stirred. The dichloromethane layer was then separated and subsequently the water layer was extracted for 6 times with 100 ml dichloromethane. After evaporation of the dichloromethane yellowish crystals remains. (yield 85%; yellowish crystals; m.p. 171-175° C.).

Workup

  1. additionwere added
  2. customThe dichloromethane layer was then separated
  3. extractionsubsequently the water layer was extracted for 6 times with 100 ml dichloromethane
  4. customAfter evaporation of the dichloromethane yellowish crystals

Sources & evidence

ORD record
ord-b5e143f5cbbc46e18c28030415920cca
Source dataset
uspto-grants-2009_06
Patent number
US07550465B2

Reaction notes

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