Hydrochloric Acid → HCID 68851263, compound

HRID 1986995Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH:15]([C:30]3([OH:36])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[CH2:16][N:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[ClH:37]>>[ClH:1].[ClH:37].[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[CH:11][C:12]([CH:15]([C:30]3([OH:36])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]3)[CH2:16][N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[CH:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68853040HCID 68853040, compound

Product 1

HCID 68851263HCID 68851263, compound

Procedure

In an analogous manner to Example 135, step 4, 1-[1-(3′,4′-dichloro-111′-biphenyl-4-yl)-2-piperazin-1-ylethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[2-(3′,4′-dichloro-1,1′-biphenyl-4-yl)-2-(1-hydroxycyclohexyl)ethyl]piperazine-1-carboxylate. MS (ESI) m/z 433 ([M+H]+); HRMS: calcd for C24H30Cl2N2O.2.00 HCl, 504.1269; found (ESI), 433.1793.

Sources & evidence

ORD record: ord-0d8a5d406382405b8c4678eb724912f1
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07550456B2

Reaction notes

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