Hydrochloric Acid → HCID 68646739, compound

HRID 1987176Notes

Reaction equation

[CH2:1]([O:3][C:4]([C@@H:6]1[C@@H:10]([C:11](=[O:27])[NH:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]3=[O:25])=[CH:15][C:14]=2[F:26])[CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1)=[O:5])[CH3:2].[ClH:35]>C(O)(C)C>[ClH:35].[CH2:1]([O:3][C:4]([C@@H:6]1[C@@H:10]([C:11](=[O:27])[NH:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]3=[O:25])=[CH:15][C:14]=2[F:26])[CH2:9][NH:8][CH2:7]1)=[O:5])[CH3:2]

Participants

Conditions

Temperature: 25 °C

Procedure

Compound 28b (5.37 g; 11 mmol) is dissolved in 6 N HCl in isopropanol (42 ml) and the mixture is stirred for 2 h at 25° C. The mixture is evaporated to dryness and the crude product is recrystallized from diethylether several times to yield compound 28c as an off-white solid. Yield: 4.89 g (105.2%), ESI-MS: m/z=374 [M+H]+

Workup

customThe mixture is evaporated to dryness
customthe crude product is recrystallized from diethylether several times

Sources & evidence

ORD record: ord-f2b293f5c112469eb175e875604eb970
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07550487B2

Reaction notes

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