Dimethyl Sulfate → HCID 86607551, compound

HRID 1987840Notes

Reaction equation

HRID 1987840 reaction equation
S(OC)(O[CH3:5])(=O)=O.[OH:8][C:9]1[C:17]2[N:13]([C:14]([C:23](=[O:35])[C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[C:26]([O:33][CH3:34])[CH:25]=3)=[C:15]([CH3:22])[C:16]=2[C:18]([O:20][CH3:21])=[O:19])[CH:12]=[CH:11][CH:10]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:5][O:8][C:9]1[C:17]2[N:13]([C:14]([C:23](=[O:35])[C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[C:26]([O:33][CH3:34])[CH:25]=3)=[C:15]([CH3:22])[C:16]=2[C:18]([O:20][CH3:21])=[O:19])[CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 11523830HCID 11523830, compound

Product 1

HCID 86607551HCID 86607551, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
60 °C

Procedure

0.19 mL (2.02 mmol) of dimethyl sulfate is added to a mixture of 705 mg (1.84 mmol) of methyl [8-hydroxy-3-(3-methoxy-4-nitrobenzoyl)-2-methylindolizin-1-yl]carboxylate obtained in Example 2, in 10 mL of acetone with 330 mg (2.39 mmol) of potassium carbonate and the medium is heated at 60° C. for 6 hours.

Sources & evidence

ORD record
ord-ac74a1b3d2964e838004891524c75be3
Source dataset
uspto-grants-2009_06
Patent number
US07553845B2

Reaction notes

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