反应详情

温度

100 °C

To a solution of 7-bromo-4-(bromoacetyl)-2H-chromen-2-one (0.605 g, 1.7 mmol) in DMF is added thioacetamide (0.138 g, 1.8 mmol). The mixture is stirred 24 h at rt and at 100° C. overnight. Once cool to rt, it is partitioned between aqueous NH4Cl and EtOAc. The layers are separated and the aqueous phase is extracted with EtOAc. The combined organic layers are washed with brine and dried over anhydrous Na2SO4. The solvent is evaporated and the residue swished in hexanes/Et2O to give the title compound.

1. temperatureOnce cool to rt
2. customit is partitioned between aqueous NH4Cl and EtOAc
3. customThe layers are separated
4. extractionthe aqueous phase is extracted with EtOAc
5. washThe combined organic layers are washed with brine
6. dry with materialdried over anhydrous Na2SO4
7. customThe solvent is evaporated