Ethyl trifluoroacetate → HCID 23504043, compound
Reaction equation
[NH2:1][CH2:2][CH:3]([OH:6])[CH2:4][OH:5].[F:7][C:8]([F:15])([F:14])[C:9](OCC)=[O:10]>O1CCCC1>[OH:6][CH:3]([CH2:4][OH:5])[CH2:2][NH:1][C:9](=[O:10])[C:8]([F:15])([F:14])[F:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
15 g of 3-aminopropan-1,2-diol (164.6 mmol) were solubilized in 100 ml of tetrahydrofuran in a round-bottomed flask provided with a magnetic bar. The reaction mixture was then cooled to 0° C. on an ice bath and 21.5 ml of ethyl trifluoroacetate (181.1 mmol) were gradually added. The reaction mixture was stirred for 2 hours at room temperature. The crude reaction product was then evaporated to dryness. 29 g of a pure colorless oil were thus obtained (yield: 95%), that product was used without further purification.
Workup
- customprovided with a magnetic bar
- customThe crude reaction product
- customwas then evaporated to dryness
Sources & evidence
- ORD record
- ord-2c2fffdf8980466986ca78334d9d860e
- Source dataset
- uspto-grants-2010_01
- Patent number
- US07641914B2
Reaction notes
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