Hydrochloric Acid → HCID 58708360, compound

HRID 1988788Notes

Reaction equation

HRID 1988788 reaction equation
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[NH:13][C:12]2=[O:20])=[CH:6][CH:5]=1.[Li+].[OH-].Cl>O1CCOCC1>[O:20]=[C:12]1[N:11]([CH2:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:21])=[O:2])=[CH:5][CH:6]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[NH:13]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 23551552HCID 23551552, compound

Product 1

HCID 58708360HCID 58708360, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
23 °C

Procedure

A solution of 4-(2-Oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-benzoic acid methyl ester (0.25 mmol) in dioxane (1 mL) was treated with aqueous LiOH (1 M, 1.0 mL). After stirring at 23° C. for 2 h, the reaction was neutralized with aqueous HCl (1 M, 2.0 mL) and the resulting solid was isolated by filtration. The filter cake was rinsed with water and allowed to dry in vacuo to yield 4-(2-Oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-benzoic acid.

Workup

  1. customthe resulting solid was isolated by filtration
  2. washThe filter cake was rinsed with water
  3. customto dry in vacuo

Sources & evidence

ORD record
ord-59dbd80b22ff4f86a0299822909ed8c4
Source dataset
uspto-grants-2010_01
Patent number
US07642275B2

Reaction notes

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