Hydrochloric Acid → HCID 68705950, compound

HRID 1988852Notes

Reaction equation

HRID 1988852 reaction equation
[ClH:1].C(OC(=O)[N:8]([C:17]1[CH:22]=[CH:21][N:20]=[C:19]2[C:23]([CH3:30])=[C:24]([CH3:29])[N:25]([CH2:26][CH:27]=[CH2:28])[C:18]=12)[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)(C)(C)C.Cl>C(OCC)(=O)C>[ClH:1].[CH2:26]([N:25]1[C:18]2[C:19](=[N:20][CH:21]=[CH:22][C:17]=2[NH:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)[C:23]([CH3:30])=[C:24]1[CH3:29])[CH:27]=[CH2:28]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68705457HCID 68705457, compound

Product 1

HCID 68705950HCID 68705950, compoundYield 44.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of (1-allyl-2,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-7-yl)-(4-fluorobenzyl)carbamic acid tert-butyl ester hydrochloride (101.3 mg) prepared in Step 1 in ethyl acetate (10 ml) was saturated with hydrochloric acid gas and then stirred for 1 hour at room temperature. The resulting precipitate was filtered and then dried to give the titled compound as a white solid (35.3 mg, 44.1%).

Workup

  1. filtrationThe resulting precipitate was filtered
  2. customdried

Sources & evidence

ORD record
ord-a1c712746aa142f1b5e66cc3e0e263b0
Source dataset
uspto-grants-2010_01
Patent number
US07642269B2

Reaction notes

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