反应详情

A mixture of 6-bromo-N-cyclopropyl-1,2-benzisoxazol-3-amine (Intermediate 53) (0.02 g) N-cyclopropyl-3-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (Intermediate 62) (0.02 g) saturated aqueous sodium hydrogen carbonate (0.5 ml) and tetrakis(triphenykphosphine)palladium(0) in isopropanol (2 ml) was heated in a microwave at 150° for 10 min. The residue was absorbed onto silica Merck 7734) and applied to a Varian Bond Elut SPE cartridge (silica, 5 g) elutin with cyclohexane:ethyl acetate (75:25 to 0:100) to give the title compound (10 mg).

1. temperaturewas heated in a microwave at 150° for 10 min
2. customThe residue was absorbed onto silica Merck 7734) and