4-Methoxybenzylamine → N-Cyclopropyl-3-fluoro-4-methyl-5-{1-[2-({[4-(methyloxy)phenyl]methyl}amino)-2-oxoethyl]-1H-indazol-5-yl}benzamide

HRID 1988950Notes

Reaction equation

HRID 1988950 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[C:9]([F:28])[C:10]([CH3:27])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23](OC)=[O:24])[N:17]=[CH:16]4)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[CH3:29][O:30][C:31]1[CH:38]=[CH:37][C:34]([CH2:35][NH2:36])=[CH:33][CH:32]=1>>[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23]([NH:36][CH2:35][C:34]3[CH:37]=[CH:38][C:31]([O:30][CH3:29])=[CH:32][CH:33]=3)=[O:24])[N:17]=[CH:16]4)[C:10]([CH3:27])=[C:9]([F:28])[CH:8]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 754524-MethoxybenzylamineHCID 58656520HCID 58656520, compound

Product 1

HCID 58656502N-Cyclopropyl-3-fluoro-4-methyl-5-{1-[2-({[4-(methyloxy)phenyl]methyl}amino)-2-oxoethyl]-1H-indazol-5-yl}benzamide

Procedure

Example 134 was prepared by General Method D using methyl (5-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-1H-indazol-1-yl)acetate (Example 123) and 4-methoxybenzylamine to give the title compound (0.012 g).

Workup

  1. customExample 134 was prepared by General Method D

Sources & evidence

ORD record
ord-b2ba7ed331294e4c9393bf4b361de3fe
Source dataset
uspto-grants-2010_01
Patent number
US07642276B2

Reaction notes

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