Phosphorus oxychloride → 2-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine

HRID 1989095Notes

Reaction equation

HRID 1989095 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[NH:12][C:11](=O)[N:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:11]1[N:10]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 574686074-(3,4-dichloro-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one

Product 1

HCID 154777402-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine

Procedure

The title compound was prepared from 4-(3,4-dichloro-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (5.72 g, 18.5 mmol) and phosphoryl chloride (60 mL) according to the general procedure I. Obtained as a white solid (6.04 g, 99%). MS (EI) 326.0 [(M)+]; mp 82° C.

Sources & evidence

ORD record
ord-dbc962a23bcb437d9cc3bf27a229853b
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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