Phosphorus oxychloride → HCID 57468661, compound

HRID 1989119Notes

Reaction equation

[F:1][C:2]([F:21])([F:20])[C:3]1[NH:8][C:7](=O)[N:6]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[CH:4]=1.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:7]1[N:8]=[C:3]([C:2]([F:21])([F:20])[F:1])[CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:6]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 57468662HCID 57468662, compound

Product 1

HCID 57468661HCID 57468661, compound

Procedure

The title compound was prepared from 6-trifluoromethyl-4-(3-trifluoromethylphenyl)-1H-pyrimidin-2-one (7.85 g, 25.5 mmol) and phosphoroxychloride (85 mL) according to the general procedure I. Obtained as a yellow solid (5.33 g, 64%). MS (EI) 326.1 [(M)+]; mp 65° C.

Sources & evidence

ORD record: ord-f131ac8af91d411b84ef5a26b628f944
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07642264B2

Reaction notes

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