Dimethylamine → HCID 57469086, compound

HRID 1989719Notes

Reaction equation

HRID 1989719 reaction equation
[CH3:1][NH:2][CH3:3].C(N(CC)CC)C.Cl.[F:12][C:13]([F:47])([F:46])[C:14]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)[N:17]=[C:16]([C:30]2[CH:35]=[CH:34][N:33]=[C:32]([C:36]3[CH:37]=[C:38]([S:42](Cl)(=[O:44])=[O:43])[CH:39]=[CH:40][CH:41]=3)[CH:31]=2)[N:15]=1>C1COCC1>[CH3:1][N:2]([CH3:3])[S:42]([C:38]1[CH:39]=[CH:40][CH:41]=[C:36]([C:32]2[CH:31]=[C:30]([C:16]3[N:15]=[C:14]([C:13]([F:12])([F:46])[F:47])[CH:19]=[C:18]([C:20]4[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:27])[F:28])=[CH:22][CH:21]=4)[N:17]=3)[CH:35]=[CH:34][N:33]=2)[CH:37]=1)(=[O:43])=[O:44]

Participants

5

Reactant 3

HCID 674DimethylamineHCID 8471TriethylamineHCID 60209344HCID 60209344, compound

Product 1

HCID 57469086HCID 57469086, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a cooled (ice-water bath) and stirred mixture of dimethylamine solution (60% in water) (0.27 ml, 3.21 mmol), triethylamine (0.29 ml, 2.1 mmol) and THF (4 ml) was added drop wise a solution of 3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-pyridin-2-yl}-benzenesulfonyl chloride hydrochloride (example I.1) (0.58 g, 1.0 mmol) in THF (6 ml). The mixture was allowed to stir at room temperature for 16 h. Purification of the reaction mixture by flash chromatography on silica gel (ethyl acetate/heptane) and crystallization (dichloromethane/MeOH/hexane) yielded the title compound as a white solid (0.5 g, 97%). MS (ISP) 552.7 [(M+H)+]; mp 225° C.

Workup

  1. stirringto stir at room temperature for 16 h
  2. customPurification of the reaction mixture by flash chromatography
  3. customon silica gel (ethyl acetate/heptane) and crystallization (dichloromethane/MeOH/hexane)

Sources & evidence

ORD record
ord-08ed1da6ee70410eabceb774217b047a
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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