Hydrochloric Acid → HCID 67460709, compound

HRID 1989860Notes

Reaction equation

HRID 1989860 reaction equation
[C:1]1([CH:7]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[CH:23]=[CH:22][C:21]([NH:24][C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[C:33]4[CH:38]=[CH:37][C:36]([C:39]([F:42])([F:41])[F:40])=[CH:35][CH:34]=4)=[O:26])=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)[C:8]([O:10]C)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:43]>>[ClH:43].[C:1]1([CH:7]([N:12]2[CH2:13][CH2:14][CH:15]([C:18]3[CH:23]=[CH:22][C:21]([NH:24][C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[C:33]4[CH:38]=[CH:37][C:36]([C:39]([F:42])([F:40])[F:41])=[CH:35][CH:34]=4)=[O:26])=[CH:20][CH:19]=3)[CH2:16][CH2:17]2)[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 17989467Methyl (2s)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate

Product 1

HCID 67460709HCID 67460709, compound

Procedure

A mixture of intermediate (11) (0.012 mol) in HCl (36%, 100 ml) was stirred and refluxed for 6 hours, then stirred overnight at room temperature. The precipitate was filtered off and triturated under 2-propanol. The precipitate was filtered off and dried, yielding 6.2 g of α-phenyl-4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]-amino]phenyl]-1-piperidineacetic acid monohydrochloride (intermediate 12).

Workup

  1. temperaturerefluxed for 6 hours
  2. stirringstirred overnight at room temperature
  3. filtrationThe precipitate was filtered off
  4. customtriturated under 2-propanol
  5. filtrationThe precipitate was filtered off
  6. customdried

Sources & evidence

ORD record
ord-1480110124144f48939ed0d06d62e574
Source dataset
uspto-grants-2010_01
Patent number
US07642378B2

Reaction notes

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