Hydrochloric Acid → HCID 68523473, compound

HRID 1989871Notes

Reaction equation

HRID 1989871 reaction equation
[C:1]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:21][CH2:20][N:19]([CH:22]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:23]([O:25]C)=[O:24])[CH2:18][CH2:17]2)=[CH:12][CH:11]=1)=[O:8].[ClH:39]>>[ClH:39].[C:27]1([CH:22]([N:19]2[CH2:20][CH2:21][N:16]([C:13]3[CH:14]=[CH:15][C:10]([NH:9][C:7]([C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=4[C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)=[O:8])=[CH:11][CH:12]=3)[CH2:17][CH2:18]2)[C:23]([OH:25])=[O:24])[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22499399Methyl 4-[4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]phenyl]-alpha-phenyl-1-piperazineacetate

Product 1

HCID 68523473HCID 68523473, compound

Procedure

A mixture of intermediate (37) (0.053 mol) in HCl (36%; 300 ml) was stirred and refluxed for 2 days, cooled, filtered and dried. The residue was triturated in 2-propanone. The precipitate was filtered off and dried, yielding 21.5 g of α-phenyl-4-[4-[([1,1′-biphenyl]-2-ylcarbonyl)amino]phenyl]-1-piperazineacetic acid hydrochloride (1:2) 2-propanolate (1:1) (intermediate 38).

Workup

  1. temperaturerefluxed for 2 days
  2. temperaturecooled
  3. filtrationfiltered
  4. customdried
  5. customThe residue was triturated in 2-propanone
  6. filtrationThe precipitate was filtered off
  7. customdried

Sources & evidence

ORD record
ord-db9b6a48c1ed49898640805e89d53909
Source dataset
uspto-grants-2010_01
Patent number
US07642378B2

Reaction notes

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