Dimethylamine → HCID 68522053, compound

HRID 1990076Notes

Reaction equation

HRID 1990076 reaction equation
[CH3:1][NH:2][CH3:3].[CH2:4]([O:6][C:7]([C:9]1[S:10][C:11](S(C)(=O)=O)=[C:12]([C:21]#[N:22])[C:13]=1[C:14]1[CH:19]=[CH:18][C:17]([I:20])=[CH:16][CH:15]=1)=[O:8])[CH3:5]>C1COCC1>[CH2:4]([O:6][C:7]([C:9]1[S:10][C:11]([N:2]([CH3:3])[CH3:1])=[C:12]([C:21]#[N:22])[C:13]=1[C:14]1[CH:19]=[CH:18][C:17]([I:20])=[CH:16][CH:15]=1)=[O:8])[CH3:5]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 68522041HCID 68522041, compound

Product 1

HCID 68522053HCID 68522053, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Add 3 mL of 2N dimethylamine in THF to 3-(4-iodophenyl)-4-cyano-5-methanesulfonyl-thiophene-2-carboxylic acid ethyl ester (0.23 mmol) and stir under nitrogen at room temperature for 2 h. Evaporate to dryness to provide the title compound which is used without further purification. Yield 95%. MS (ES+, m/e)=427 (M++1).

Workup

  1. customEvaporate to dryness

Sources & evidence

ORD record
ord-3bf257af067040969837c0bf03c2d292
Source dataset
uspto-grants-2010_01
Patent number
US07642361B2

Reaction notes

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