HRID1990076

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID674

Dimethylamine

C2H7N

结构：CCOC(=O)c1sc(S(C)(=O)=O)c(C#N)c1-c1ccc(I)cc1

HCID68522041

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1sc(N(C)C)c(C#N)c1-c1ccc(I)cc1

HCID68522053

未命名化合物

收率 95%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Add 3 mL of 2N dimethylamine in THF to 3-(4-iodophenyl)-4-cyano-5-methanesulfonyl-thiophene-2-carboxylic acid ethyl ester (0.23 mmol) and stir under nitrogen at room temperature for 2 h. Evaporate to dryness to provide the title compound which is used without further purification. Yield 95%. MS (ES+, m/e)=427 (M++1).

WORKUP

后处理

customEvaporate to dryness