Dimethylamine → HCID 58873203, compound

HRID 1990091Notes

Reaction equation

HRID 1990091 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[S:7][C:8](S(C)(=O)=O)=[C:9]([C:25]#[N:26])[C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:23]#[N:24])=[CH:13][CH:12]=1)=[O:5])[CH3:2].[CH3:31][NH:32][CH3:33]>C1COCC1>[CH2:1]([O:3][C:4]([C:6]1[S:7][C:8]([N:32]([CH3:33])[CH3:31])=[C:9]([C:25]#[N:26])[C:10]=1[C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:23]#[N:24])=[CH:15][CH:16]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 58873081HCID 58873081, compound

Product 1

HCID 58873203HCID 58873203, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Add 4-cyano-3-(2′-cyano-biphenyl-4-yl)-5-methanesulfonyl-thiophene-2-carboxylic acid ethyl ester (100 mg, 0.23 mmol) to 3 mL of 2N dimethylamine in THF and stir under nitrogen at room temperature for 90 minutes. Evaporate to a tan solid which is used without further purification. MS(ES+, m/e)=402 (M++1); HPLC=89%.

Workup

  1. customEvaporate to a tan solid which
  2. customis used without further purification

Sources & evidence

ORD record
ord-8bc41672fc23463ab3183565ad4486b2
Source dataset
uspto-grants-2010_01
Patent number
US07642361B2

Reaction notes

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