Hydrochloric Acid → HCID 16046205, compound

HRID 1990106Notes

Reaction equation

HRID 1990106 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[S:9][C:10]([S:25][CH3:26])=[C:11]([C:23]#[N:24])[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:15][CH:14]=1)=[O:7])C.Cl>C(O)C>[C:19]([C:16]1[CH:15]=[CH:14][C:13]([C:12]2[C:11]([C:23]#[N:24])=[C:10]([S:25][CH3:26])[S:9][C:8]=2[C:6]([OH:7])=[O:5])=[CH:18][CH:17]=1)([CH3:22])([CH3:20])[CH3:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 44416703HCID 44416703, compound

Product 1

HCID 16046205HCID 16046205, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Add NaOH 1M (1 ml) to a suspension of 3-(4-tert-butyl-phenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl ester (general preparation 28, general preparation 29, general example E-1) (0.128 mmol) in ethanol (1 ml) and stir 24 h. Add 6 N HCl until pH approx. 1 and white solid precipitates. Filter the solid to provide the title compound: MS (ES+, m/e): 332 (M+1).

Workup

  1. customprecipitates
  2. filtrationFilter the solid

Sources & evidence

ORD record
ord-36b72f33e562482eabfbf59c872b1939
Source dataset
uspto-grants-2010_01
Patent number
US07642361B2

Reaction notes

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